Remark: Barbiturates may improve adverse effects, which include respiratory depression, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates enhance metabolism and decrease blood concentrations of TCAs.
pentobarbital will lessen the extent or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will decrease the extent or result of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. The efficacy of hormonal contraceptives can be diminished.
pentobarbital will lower the level or impact of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with strong CYP3A4 inducers may lead to lowered serum concentrations and loss of antimalarial efficacy
pentobarbital will lessen the extent or impact of bedaquiline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Keep away from coadministration of bedaquiline with powerful CYP3A4 inducers as a consequence of likely for diminished therapeutic effect
Contraindicated. Coadministration of doravirine with a solid CYP3A inducer may website well minimize doravirine plasma concentrations and/or effects. Opportunity for loss of virologic response and achievable resistance to doravirine.
pentobarbital will decrease the extent or result of pimozide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unidentified.
pentobarbital will lessen the extent or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
pentobarbital will lower the extent or influence of venetoclax by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Contraindicated (1)pentobarbital will reduce the level or outcome of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the extent or result of cortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
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pentobarbital will lower the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will decrease the extent or influence of ziprasidone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.